The O's took the series over Chicago after a 5-3 win on Thursday afternoon.
Jason Hammel (2-0) picked up his second win in three attempts, allowing just two runs on six hits and three walks over six innings, striking out ten.
The bullpen continued to impress, and although Jim Johnson loaded the bases in the ninth, he notched his sixth save in six tries and 14th straight overall dating back to last season.
Adam Jones went 2-for-4 with three RBIs and hit his team-leading fifth long-ball in the fifth inning.
The O's take on the Angels for three games starting late Friday night; Brian Matusz takes the mound for the Birds.